ULTIMATE EDITION

For the treatment of Melasma, Redness, PIH, Scars,
Tightening & Pores

The World’s 1st FDA-Approved Pulsed Wave and Continuous Wave Radio Frequency Microneedling System

TREATS MELASMA

MINIMIZES WRINKLES

TREATS PIH

SKIN REJUVENATION

TREATS REDNESS

TREATS ROSACEA

MINIMISES PORES

REDUCES STRETCH MARKS

LIFTS & TIGHTENS

TREATS ACNE SCARS

TREATS ACNE

PROMOTE SCALP CIRCULATION

A New Paradigm Approach To Radio Frequency Microneedling

The world's first and only treatment of its kind featuring both scientifically advanced Sylfirm X Ultimate Edition dual wave radio frequency microneedling device and Exosome Technology* to supercharge and X-Cellerate treatment results.

Introducing A Recommended Product For

Combine To Maximize The Results

The Next Small Thing…

Nanoparticles Offering a New Future

Exosome Regenerative Complex

For Skin

EXO Balm

Exosome Regenerative Complex+

For Skin & Scalp

Science &
Technology

What are Exosomes?

BENEV Exosome treatments are based on the most cutting edge scientific biotech breakthrough for skin rejuvenation and regeneration. Exosomes are responsible for cell to cell communication and for facilitating the exchange of RNA and other important proteins between cells (e.g. fibroblasts, keratinocytes, immune cells, etc.), in addition to transferring numerous growth factors and cytokines and genetic materials that have shown signs of tissue repair and improving skin cells. These data coding avatars have been harnessed for our new line of exosome products to promote a more radiant youthful appearance.

IN VIVO TESTING

Exosomes are nano-sized vesicles (30–200 nm) constantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids, makes them an appealing cell-free therapy option to treat multiple diseases. Here, we investigated for the first time whether human adipose tissue-derived mesenchymal stem cell-derived exosomes can ameliorate atopic dermatitis (AD) in an in vivo mouse model. When injected either intravenously (IV) or subcutaneously (SC) into NC/Nga mice treated with house dust mite antigens, ERC-exosomes were found to reduce pathological symptoms such as clinical score, the levels of serum IgE, the number of eosinophils in blood, and the infiltration of mast cells, CD86+, and CD206+ cells in skin lesions. ERC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor (TNF-) in AD skin lesions of Nc/Nga mice. Taken together, these results suggest that ERC-exosomes can be a novel promising cell-free therapeutic modality for AD treatment. (Byong Seung Cho, Jin Ock Kim, Dae Hyun Ha and Yong Weon – Stem Cell Research Therapy, BioMedCentral.com)

Before & After Treatment

CELEBRITIES CHOICE® COSMETIC SURGERY

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